The effectiveness of a feed additive with galloisite in rat mycotoxicosis

Federal Center for Toxicological, Radiation and Biological Safety, 2 Nauchny Gorodok, Kazan, 420075, Russia

Abstract

The paper presents the results of assessing the effectiveness of a complex feed additive based on halloysite for experimental T-2, afla- and zearalenone toxicosis of white rats in terms of survival, changes in clinical condition, enzyme status of blood serum and spleen ultrastructure. The results presented in the article confirmed the danger of the combined effects of mycotoxins on the body of white rats. The presence of mycotoxins in the feed led to the death of 30.0% of rats with a change in the clinical condition of the surviving animals, a significant increase in the serum levels of aminotransferases, alkaline phosphatase, lactate dehydrogenase, creatine kinase and gamma-glutamyltransferase, as well as changes in the ultrastructure of the spleen. A normalizing effect of a food additive based on halloysite on the studied parameters in experimental combined mycotoxicosis was noted, which was manifested by 100% survival of rats, less pronounced changes in the enzyme status and a protective effect on the ultrastructure of the spleen. This makes it promising for further comprehensive research on productive animal species with the prospect of implementation in animal husbandry as an effective means of preventing combined mycotoxicoses.